New drug to treat resistant high blood pressure

High blood pressure, also referred to as hypertension, is a major risk factor for cardiovascular disease-related morbidity and mortality worldwide. 

Many patients struggling with uncontrolled high blood pressure, or resistant blood pressure, have no other option but to rely on mineralocorticoid receptor antagonists (MRAs), despite the risk of side effects such as hyperkalemia and hormonal disorders.

^{(Shutterstock)}

However, a new type of medication, called Lorundrostat, has shown promise in early clinical trials. The drug works by reducing the body’s production of aldosterone, a hormone secreted by the adrenal gland to help regulate blood pressure by controlling sodium and potassium levels.

The drug has the potential to provide an alternative to MRAs for patients with resistant hypertension, including obese patients.

According to preventive cardiology specialist, Luke Lavin, and co-director of the Center for Blood Pressure Diseases at the Cleveland Clinic, these early studies are encouraging.

The second phase of the multi-center clinical trial for Lorundrostat showed significant effectiveness in safely lowering high blood pressure in patients.

The study results were published this month in the Journal of the American Medical Association.

^{(Shutterstock)}

While the drug is still in its early stages and further testing is needed, this development is exciting for patients with resistant hypertension who haven’t found relief with traditional medications.

Dr. Lavin emphasized the importance of lifestyle changes in managing high blood pressure. A healthy diet that includes fruits, vegetables, whole grains, fish, and lean meat, as well as regular exercise, can also help lower blood pressure levels.

Quitting smoking, avoiding alcohol, and reducing salt, trans fats, and saturated fats are equally crucial.

^{(Shutterstock)}

It’s important for patients to work closely with their healthcare provider to manage their blood pressure effectively.

Dr. Lavin advises patients to take medications as prescribed and to stay in communication with their doctor if their high blood pressure persists.

With that said, it’s crucial to remember that lifestyle changes are also crucial for blood pressure management and that medications aren’t the only thing that has an effect.