Woman back on dialysis after pig kidney transplant fails

Lisa Pisano, the second person to undergo a groundbreaking pig kidney transplant, is back on dialysis after surgeons removed the failing organ just 47 days post-operation. NYU Langone Health confirmed her stable condition following the removal earlier this week.

Pisano’s journey mirrors that of Richard “Rick” Slayman, the first recipient, who passed away in early May, nearly two months after his transplant at Massachusetts General Hospital. Despite no indication that Slayman’s death was linked to the experimental procedure, his outcome added weight to Pisano’s uncertain path.

Facing failing heart and kidneys, Pisano underwent two dramatic surgeries in April: the implantation of a mechanical heart pump followed by the pig kidney transplant. Initial recovery seemed promising, but managing the heart pump alongside the new kidney posed “unique challenges,” according to Dr. Robert Montgomery, lead surgeon.

Repeated episodes of low blood pressure compromised optimal blood flow to the kidney, leading to its gradual decline in function. Despite no signs of rejection in recent biopsies, insufficient blood flow caused significant injury, rendering continued immune-suppressing medications unjustifiable.

Montgomery expressed hope in Pisano’s swift return to her family, acknowledging her courage and resilience amid adversity. Pisano’s heart condition precludes her from the heart pump while on dialysis, and traditional kidney transplant is barred due to her heart disease.

Pisano’s decision to undergo the experimental procedure reflects the urgent need for transplant alternatives. Over 100,000 individuals await transplants in the U.S., with most needing kidneys, and thousands perish while waiting. Biotech companies are exploring solutions, genetically modifying pigs to create organs more akin to humans, thus reducing the likelihood of rejection.

As NYU delves into studying the explanted kidney for insights, Pisano’s story underscores the complexities and hopes entwined in the pursuit of xenotransplantation—the promise of bridging the organ shortage chasm with innovative solutions.