Worth a shot? How one-dose COVID jab could help in pandemic fight
A vaccine developed by Johnson & Johnson is close to becoming the first single-dose COVID-19 shot to be approved by regulators in the United States, a key first step towards international approval of a jab that could change how vaccines are administered globally.
The drug company filed an application on Thursday to the US Food and Drug Administration (FDA) after preliminary clinical trial results showed it was 66-percent effective overall and offered 85-percent protection against severe illness 28 days after inoculation.
The FDA has scheduled a meeting for February 26 to discuss the data and decide whether to grant emergency use authorisation. The vaccine is also being reviewed by health authorities around the world.
If approved by the US regulator, the company plans to apply for international approvals, something experts say could boost the global vaccination campaign, which has stalled in some regions as manufacturers reported supply chain issues.
What are the advantages of the Johnson & Johnson shot?
The Johnson & Johnson shot’s efficacy rate is lower than the two other vaccines from Pfizer-BioNTech and Moderna, which showed 95-percent and 94-percent efficacy respectively.
Unlike the other two vaccines though, it does not require a second dose, which would simplify logistical challenges in the roll-out.
“It’s a very positive development because it is a single dose and can be transported, and stored, in normal temperature so operationally and logistically it is a game-changer,” said the World Health Organization’s chief scientist Soumya Swaminathan.
The vaccine can be kept in regular refrigerators between 2C and 8C (36 F and 46 F) for three months, compared with other vaccines that need to be kept at ultra-cold temperatures. This could aid distribution in rural and remote populations.
“And the higher the number of people we vaccinate, the easier it is to cover the effect of new variants,” Swaminathan added.
Does it work against new variants?
Viruses mutate regularly when they replicate in order to spread and thrive, and the coronavirus has undergone many mutations since it was first discovered in the Chinese city of Wuhan in late 2019.
“When a virus replicates itself, it can make ‘errors’ generating new variants that could spread faster or have a higher mortality rate,” said Zoltan Kis, Research Associate at the Future Vaccine Manufacturing Hub at Imperial College London.
In the worst case scenario, Kis explained, you can have a variant that is so different from the original copy that it requires a new vaccine.
Scientists have identified new variants in the United Kingdom, Brazil and South Africa in recent months which appear to be more transmissible than previous variants of the virus.
The clinical trials of the Johnson & Johnson vaccine that were carried out in the United States, Latin America and South Africa showed an efficacy rate against moderate to severe infection of 72 percent, 66 percent and 57 percent, respectively.
The drop in efficacy in the South Africa trial, which has been seen with other vaccines, is linked to a new strain of the virus, the B.1.351, which appears to be more resistant to the body’s antibody response. Still, the one-shot vaccine offered high protection against severe illness in the South African trial.
