Canada clears Johnson & Johnson vaccine, its fourth option

Canada is getting a fourth vaccine to prevent COVID-19 as the country’s health regulator has cleared a Johnson & Johnson shot that works with just one dose instead of two, officials said on Friday.

Health experts are eager for a one-and-done option to help speed vaccination. Canada has also approved vaccines from Pfizer, Moderna and AstraZeneca and Health Canada is the first significant regulator to approve four different vaccines, said Dr Supriya Sharma, Health Canada’s chief medical adviser.

Canada is getting a fourth vaccine to prevent COVID-19 as the country’s health regulator has cleared a Johnson & Johnson shot that works with just one dose instead of two, officials said on Friday.

Health experts are eager for a one-and-done option to help speed vaccination. Canada has also approved vaccines from Pfizer, Moderna and AstraZeneca and Health Canada is the first significant regulator to approve four different vaccines, said Dr Supriya Sharma, Health Canada’s chief medical adviser.

The US approved Johnson and Johnson last month. The US Food and Drug Administration said J&J’s vaccine offers strong protection against what matters most: serious illness, hospitalisations and death. One dose was 85 percent protective against the most severe COVID-19 illness in a massive study that spanned three continents – protection that remained strong even in countries such as South Africa, where the variants of most concern are spreading.

J&J also is seeking authorisation for emergency use of its vaccine in Europe and from the World Health Organization. The company aims to produce about 1 billion doses globally by the end of the year. Last month, the island nation of Bahrain became the first to clear its use.

The vaccine shortage is so acute in Canada that provincial governments are now saying they will extend the interval between the two doses of Pfizer, Moderna and AstraZeneca vaccines to four months rather than three to four weeks so they can quickly inoculate more people.

“It is a reasonable recommendation. If we can get earlier doses, we don’t have to wait for four months to give second doses if the supply opens up,” Sharma said.

Canadians 80 years old and above are only starting to get vaccinated this month and the National Advisory Committee on Immunization said this week that extending the dose interval to four months would allow as many as 80 percent of Canadians over the age of 16 to receive a single dose by the end of June simply with the expected supply of Pfizer-BioNTech and Moderna vaccines.

 

Second doses would begin to be administered in July as more shipments arrive, the panel said.

Canada also faces the prospect of vaccine delivery disruptions from the European Union. A shipment of over a quarter million AstraZeneca vaccines destined for Australia has been blocked from leaving the European Union in the first use of an export control system instituted by the bloc to make sure big pharma companies respect their local contracts.

J&J’s shot uses a cold virus like a Trojan horse to carry the spike gene into the body, where cells make harmless copies of the protein to prime the immune system in case the real virus comes along. It’s the same technology the company used in making an Ebola vaccine, and is similar to COVID-19 vaccines made by AstraZeneca and China’s CanSino Biologics.

The Pfizer and Moderna vaccines are made with a different technology, a piece of genetic code called messenger RNA that spurs cells to make those harmless spike copies.

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